I've been using these when I sleep for a few years now, and just the other night I forgot to put one on as I went to sleep. Boy, could I tell the difference. I don't understand why they make such a big difference, but they do. They don't interfere with my CPAP mask, which is especially nice.I use the clear extra-strength strips because the clear strips adhere well, but don't peel my skin off when I remove them in the morning like the pink ones do, and the extra-strength is big enough for my honkin' huge schnozz. They say most people don't need bigger/stronger strips, but I definitely do.